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**Characterization of Oral Antibiotics for Acne Treatment**
Objective: Aim 1: Characterize the international distribution of oral antibiotic use for acne in the pediatric and young adult population ages 12 to 21. Aim 2: Characterize the international distribution of oral antibiotic use for acne in the adult population ages 22 to 60.
Rationale: Acne is a common and disabling medical problem, especially among adolescents.[1] Guidelines established by the American Academy of Dermatology (AAD) recommend to minimize the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] A recent systematic review demonstrated that over 50% of P acnes strains are reported as resistant in all major regions of the world.[2] In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis, and possible associations with inflammatory bowel disease and obesity.[3] Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[3] A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[3] OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance.
Project Lead(s): Chante Karimkhani, Robert P. Dellavalle, Lisa M. Schilling,
Full Draft Protocol: acne_abx_characterization_protocol.docx
Please provide any comments or suggestions. Forum Discussion Thread
http://forums.ohdsi.org/t/ohdsi-study-concordance-with-antibiotic-treatment-guidelines-for-acne/1703
