Observational Health Data Sciences and Informatics

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====== Investigating Birth Month-Disease Risk Relationships Across the OHDSI Network======

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**Objective:** Derive data on birth month-disease risk relationships from large healthcare organizations/hospitals and healthcare facilities across the United States of America and throughout the world. Integrative analysis will be performed using established climate models, and knowledge of environmental factors that vary by season and climate.

**Rationale:** Many studies on birth month-disease relationships exist in the epidemiology literature. However, these studies are plagued by publication and disease selection biases. Therefore, we developed a high-throughput algorithm that uses Electronic Health Record data recorded during the clinical encounter and uncovers diseases with statistically significant birth month dependencies. These relationships are thought to be due to environmental exposures that occurring during development (i.e., either prenatal or perinatal effects). We call our algorithm SeaWAS: Season-Wide Association Study. However it is a "phenome-wide" approach whereby it investigates relationships between all diseases recorded in the EHR and birth month (assuming certain prevalence thresholds are met). Our algorithm runs in R and uses the OMOP CDM. Therefore, we are interested in implementing a new study that uses the OHDSI research network to run our analyses at multiple sites with different environmental exposures. This should enable us to tease out the relationship between the environmental factor and its contribution to increased or decreased disease risk.

**Project Lead(s):** Mary Regina Boland, George Hripcsak, Nicholas P Tatonetti 
 
**Coordinating Institution(s):** Columbia University

** Additional Participants (currently seeking additional collaborators):** 
  * Taipei Medical University: Jack Li, Usman Iqbal, Alex Nguyen, Martjin Schuemie
  * Ajou University School of Medicine: Rae Woong Park, Seng Chan You
  * University of Colorado: Lisa Schilling, Amanda Dempsey, Michael Kahn
  * Children's Hospital of Philadelphia: Charles Bailey
  * Erasmus University Medical Center: Peter Rijnbeek
  * Others: Adler Perotte, Patrick Ryan, Marc Suchard, Vojtech Huser


 
Any interested collaborators please contact me (Mary Regina Boland) at mb3402@columbia.edu and I will be happy to add you to the collaborator list. 

**Participating Institution(s):** Columbia University, Ajou University School of Medicine, Taipei Medical University (TMU), University of Colorado, Children's Hospital of Philadelphia (April Discussion on Forum), Erasmus University Medical Center (April Discussion on Forum)

**Full Protocol:** [[https://docs.google.com/document/d/18kizSxfKgBQU-BYDVNqDgolBBPK57kRKcONudXjTBzo/edit?usp=sharing|OHDSI Climate/Birth Month Disease Risk Protocol]]

**Initial Proposal Date:**  5/16/2015

**Launch Date:** 8/18/2015

**Receive Results for Analysis Date:**  05/01/2016

**Study Closure Date:  //<fill out once finalized>//**

**Results Submission:** [[mailto:mb3402@columbia.edu|Email]] or SFTP

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===== Customizable OHDSI-Formatted IRB =====
**IRB:** [[https://docs.google.com/document/d/1ApqNkCXWpmgg5gS3OQkqD21HoIPk3qU5j4gKd2DF6kY/edit?usp=sharing|OHDSI Climate/Birth Month Disease Risk Customizable IRB]]



===== Requirements =====
**CDM:** V4 or V5 (both versions fully tested)

**Table Accessed:**  CONDITION_OCCURRENCE, CONDITION_ERA, CONCEPT, PERSON

**Database Dialects:** SQL Server, Postgres, Oracle

**Software:** SQL and R 


===== Code ===== 
[[https://github.com/maryreginaboland/SeaWAS|GitHub code for Proposed Study 4 - SeaWAS Across OHDSI]]

===== Discussion ===== 
[[http://forums.ohdsi.org/t/ohdsi-study-4-investigating-birth-month-disease-risk-relationships-across-the-ohdsi-network/742/3|SeaWAS-OHDSI Discussion Thread]] 
===== Datasets Run ===== 
  * Columbia University - CUMC/NYP
  * Taipei Medical University
  * Ajou University School of Medicine

===== Waiting for Datasets From ===== 
  * University of Colorado
  * Collaborators (External to OHDSI)
  * Possibly - Children's Hospital of Philadelphia 
  * Possibly - Erasmus University Medical Center
~~NOTOC~~
Observational Health Data Sciences and Informatics

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