====== Incidence of exposure to drugs for which pre-emptive pharmacogenomic testing is available  ======

<WRAP box justify round>

**Objective:** Derive data that large healthcare organizations can combine with data on risks of adverse events  and cost data to conduct cost-effectiveness / cost-benefit analyses for pre-emptive pharmacogenomics testing

**Rationale:** Very few studies have been conducted that report on the potential return on investment for pre-emptive pharmacogenomics testing. The studies that have been published  suggest that pre-emptive pharmacogenomics testing may produce a return on investment but much depends on if a sufficient number of drugs with pharmacogenes are covered by a single test. Since the current data are limited to relatively localized settings and might not be of generalizable use to other health organizations, it's of interest to implement a new study using the OHDSI research network. 

**Project Lead(s):** Richard D. Boyce, Matthias Samwald

**Coordinating Institution(s):** University of Pittsburgh, Medical University of Vienna, Columbia University, Regenstrief Institute, Janssen R&D, AstraZeneca

** Additional Participants (currently seeking other collaborators):**  Patrick Ryan, Jon Duke, George Hripcsak, Abraham G. Hartzema, Christian Reich, Dan Malone 

**Full Protocol:** [[https://docs.google.com/document/d/1u3AE5DtkEp3m8OcbwkGHtXBVefYGGJ_1RMO3OnqpXiY/edit|Google doc for the protocol]]

**Initial Proposal Date:**  2/16/2015

**Launch Date:**  This was a test research network study and has met its objectives as of 12/1/2016.

**Study Closure Date:  //<fill out once finalized>//**

**Results Submission:** //<method of sumission, eg. [[mailto:contact@ohdsi.org|Email]] or SFTP>//

</WRAP>

===== Requirements =====
**CDM:** V4 or V5

**Table Accessed:**  DRUG_EXPOSURE, CONCEPT_ANCESTOR, CONCEPT_RELATIONSHIP, PERSON

**Database Dialects:** SQL Server, Postgres, Oracle

**Software:** SQL and R 
 
===== Code ===== 
[[https://github.com/OHDSI/StudyProtocols/tree/master/PGxDrugStudy|GitHub code for Proposed Study 3 - Incidence of exposure to PGx drugs]]

===== Discussion ===== 
[[http://forums.ohdsi.org/t/ohdsi-study-3-incidence-of-exposure-to-drugs-for-which-pre-emptive-pharmacogenomic-testing-is-available/387]]



===== Datasets Run ===== 
  * Truven CCAE in the IMEDS lab
  * Truven MDCD in the IMEDS lab
  * Truven MDCR in the IMEDS lab


~~NOTOC~~