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projects:workgroups:transfusion [2019/12/13 02:37]
cgreich
projects:workgroups:transfusion [2019/12/13 04:05]
cgreich
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 ==== OHDSI Transfusion Working Group ==== ==== OHDSI Transfusion Working Group ====
 +
 +<WRAP box justify round>
  
 === MISSION === === MISSION ===
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 Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://​www.nhlbi.nih.gov/​science/​recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap. Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://​www.nhlbi.nih.gov/​science/​recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap.
  
-* Use Cases: +</​WRAP>​
- * Effect of number of units on outcomes +
- * Effect of single donor vs pooled on outcomes +
- * Effect agency blood products are obtained from (such as ARC vs NYBC) on outcomes +
- * Incidence rates of severe outcomes: TRALI, TACO, Sepsis, HTRs, PTP, thrombosis and others +
- * Fatality rates of outcomes +
- * Incidence rates of outcomes by specific blood products transfused: red blood cells, plasma, platelets, full blood +
- * Incidence rates of outcomes by blood component processing: leukocyte reduction, irradiation,​ pathogen-reduction +
- * Incidence rates of outcomes by indication and associated procedures and other possible risk factors +
- * Incidence rates of outcomes by donor characteristics +
- +
-* Modelling Isues:+
  
- * Detailed facts about transfused units, such as  +== Use Cases ==
-  * Manipulation:​ cultured enrichment, demineralization,​ genetical modification,​ +
-  * Concentration,​ dosage, portioning and unit of issue, +
-  * Preservation:​ irradiation and pathogen reduction, transport, storage, cryoprotection,​ +
-  * monitoring: preparation,​ processing, mobilization,​ modification,​ quarantine,  +
-  * Additive, excipient and nutrient content+
  
-donor poolingexposure ​and type+  * Effect of number of units on outcomes 
 +  * Effect of single ​donor vs pooled on outcomes 
 +  * Effect agency blood products are obtained from (such as ARC vs NYBC) on outcomes 
 +  * Incidence rates of severe outcomes: TRALITACO, Sepsis, HTRs, PTP, thrombosis ​and others 
 +  * Fatality rates of outcomes 
 +  * Incidence rates of outcomes by specific blood products transfused: red blood cells, plasma, platelets, full blood 
 +  * Incidence rates of outcomes by blood component processing: leukocyte reduction, irradiation,​ pathogen-reduction 
 +  * Incidence rates of outcomes by indication and associated procedures and other possible risk factors 
 +  * Incidence rates of outcomes by donor characteristics
  
 +== Modelling Issues ==
  
 +  * Detailed facts about transfused units, such as 
 +   * Manipulation:​ cultured enrichment, demineralization,​ genetical modification,​
 +   * Concentration,​ dosage, portioning and unit of issue,
 +   * Preservation:​ irradiation and pathogen reduction, transport, storage, cryoprotection,​
 +   * monitoring: preparation,​ processing, mobilization,​ modification,​ quarantine, ​
 +   * Additive, excipient and nutrient content
 +  * Dose
 +  * Units
 +  * Route
 +  * Start/End Time
 +  * Multiple touch points of interest (prescribe/​dispense/​admin)
 +  * Lab results specific to the unit for unit-specific data (product CD34+ vs patient CD34+)
  
 * [[projects:​workgroups:​transfusion:​members|Participants]] * [[projects:​workgroups:​transfusion:​members|Participants]]
projects/workgroups/transfusion.txt · Last modified: 2019/12/13 04:05 by cgreich