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projects:workgroups:transfusion [2019/11/29 14:36]
cgreich
projects:workgroups:transfusion [2019/12/13 04:05] (current)
cgreich
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 ==== OHDSI Transfusion Working Group ==== ==== OHDSI Transfusion Working Group ====
  
 +<WRAP box justify round>
  
-=== MISSIONExtend OMOP CDM and Vocabulary and OHDSI analytic platform to support transfusion research ​===+=== MISSION ​=== 
 + 
 +Extend OMOP CDM and Vocabulary and OHDSI analytic platform to support transfusion research
    
-[[documentation:transfusion:​proposals|Documentation]]+Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://​www.nhlbi.nih.gov/​science/​recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap. 
 + 
 +</​WRAP>​ 
 + 
 +== Use Cases == 
 + 
 +  * Effect of number of units on outcomes 
 +  * Effect of single donor vs pooled on outcomes 
 +  * Effect agency blood products are obtained from (such as ARC vs NYBC) on outcomes 
 +  * Incidence rates of severe outcomes: TRALI, TACO, Sepsis, HTRs, PTP, thrombosis and others 
 +  * Fatality rates of outcomes 
 +  * Incidence rates of outcomes by specific blood products transfused: red blood cells, plasma, platelets, full blood 
 +  * Incidence rates of outcomes by blood component processing: leukocyte reduction, irradiation,​ pathogen-reduction 
 +  * Incidence rates of outcomes by indication and associated procedures and other possible risk factors 
 +  * Incidence rates of outcomes by donor characteristics 
 + 
 +== Modelling Issues == 
 + 
 +  * Detailed facts about transfused units, such as  
 +   * Manipulation:​ cultured enrichment, demineralization,​ genetical modification,​ 
 +   * Concentration,​ dosage, portioning and unit of issue, 
 +   * Preservation:​ irradiation and pathogen reduction, transport, storage, cryoprotection,​ 
 +   * monitoring: preparation,​ processing, mobilization,​ modification,​ quarantine,  
 +   * Additive, excipient and nutrient content 
 +  * Dose 
 +  * Units 
 +  * Route 
 +  * Start/End Time 
 +  * Multiple touch points of interest (prescribe/​dispense/​admin) 
 +  * Lab results specific to the unit for unit-specific data (product CD34+ vs patient CD34+)
  
 * [[projects:​workgroups:​transfusion:​members|Participants]] * [[projects:​workgroups:​transfusion:​members|Participants]]
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 * [[documentation:​transfusion:​Data_Source|Data Repository]] * [[documentation:​transfusion:​Data_Source|Data Repository]]
 +
  
  
  
projects/workgroups/transfusion.1575038198.txt.gz · Last modified: 2019/11/29 14:36 by cgreich