research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris
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research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2017/10/31 15:43] maura_beaton |
research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2020/04/29 21:09] crundle |
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| **Objective:** | **Objective:** | ||
| - | Aim 1: Characterize the international distribution of oral antibiotic use for acne in the pediatric and young adult population ages 12 to 21. | + | Aim 1: Characterize the international distribution of oral antibiotic use for acne in the pediatric and young adult population ages 12 to 20. |
| - | Aim 2: Characterize the international distribution of oral antibiotic use for acne in the adult population ages 22 to 60. | + | Aim 2: Characterize the international distribution of oral antibiotic use for acne in the adult population ages 21 to 40. |
| //**Rationale:** // | //**Rationale:** // | ||
| Acne is a common and disabling medical condition, particularly amongst adolescents and young adults.[1] According to the Global Burden of Disease Study 2016, acne is the most disabling skin condition worldwide, responsible for 0.28% of global burden from all diseases.[2] In addition to physical disfigurement, the profound psychosocial effects of acne have been recognized for over half a century.[3] Guidelines established by the American Academy of Dermatology recommend minimizing the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] A recent systematic review demonstrated that over 50% of P. acnes strains are reported as resistant in all major regions of the world.[4] In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis, as well as possible associations with inflammatory bowel disease and obesity.[5] Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[5] A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[5] A similar retrospective cohort study of teenagers and young adults in the US found that 18% of antibiotic courses exceeded 6 months.[6] Our study will investigate oral antibiotic use for acne over the last ten years across the globe in both pediatric/young adult and adult populations. OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance//.// | Acne is a common and disabling medical condition, particularly amongst adolescents and young adults.[1] According to the Global Burden of Disease Study 2016, acne is the most disabling skin condition worldwide, responsible for 0.28% of global burden from all diseases.[2] In addition to physical disfigurement, the profound psychosocial effects of acne have been recognized for over half a century.[3] Guidelines established by the American Academy of Dermatology recommend minimizing the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] A recent systematic review demonstrated that over 50% of P. acnes strains are reported as resistant in all major regions of the world.[4] In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis, as well as possible associations with inflammatory bowel disease and obesity.[5] Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[5] A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[5] A similar retrospective cohort study of teenagers and young adults in the US found that 18% of antibiotic courses exceeded 6 months.[6] Our study will investigate oral antibiotic use for acne over the last ten years across the globe in both pediatric/young adult and adult populations. OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance//.// | ||
| - | **Project Lead(s):** //Chante Karimkhani, Robert P. Dellavalle, Lisa M. Schilling// | + | **Project Lead(s):** //Robert P. Dellavalle, Lisa M. Schilling// |
| **Coordinating Institution(s):** //University of Colorado School of Medicine// | **Coordinating Institution(s):** //University of Colorado School of Medicine// | ||
| - | **Additional Participants:** // // | + | **Additional Participants:** // //Chante Karimkhani: ck2525@caa.columbia.edu |
| + | Chandler Rundle: chandler.rundle@gmail.com | ||
| + | Megan Branda: MEGAN.BRANDA@cuanschutz.edu | ||
| + | John Barbieri: john.barbieri@uphs.upenn.edu | ||
| + | Chris Knoll: cknoll1@its.jnj.com | ||
| + | David Margolis: margo@mail.med.upenn.edu | ||
| + | Patrick Ryan: ryan@ohdsi.org | ||
| + | Martijn Schuemie: m.schuemie@erasmusmc.nl | ||
| + | Jonathan Silverberg: JonathanISilverberg@gmail.com | ||
| + | Dylan Ray: DYLAN.RAY@cuanschutz.edu | ||
| + | Sara Deakyne: Sara.DeakyneDavies@childrenscolorado.org | ||
| **Full Draft Protocol:** //Please provide any comments or suggestions.// | **Full Draft Protocol:** //Please provide any comments or suggestions.// | ||
| - | [[https://docs.google.com/document/d/1baPHccNGfQtUNEY-bzIqTGGz7E8zbMBS_62nKDI8kGo/edit#]] | + | [[https://docs.google.com/document/d/1LnugUQrloOn-3cZJDdTpgVYEsynu7SBztFtjzjAuEDE/edit]] |
| **Initial Proposal Date:** //25 August 2016// | **Initial Proposal Date:** //25 August 2016// | ||
research/concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris.txt · Last modified: 2020/04/29 21:09 by crundle
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