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research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris

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research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2017/10/31 15:43]
maura_beaton
research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2020/01/06 13:28] (current)
crundle
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 **Objective:​** ​ **Objective:​** ​
-Aim 1: Characterize the international distribution of oral antibiotic use for acne in the pediatric and young adult population ages 12 to 21+Aim 1: Characterize the international distribution of oral antibiotic use for acne in the pediatric and young adult population ages 12 to 20
-Aim 2: Characterize the international distribution of oral antibiotic use for acne in the adult population ages 22 to 60.+Aim 2: Characterize the international distribution of oral antibiotic use for acne in the adult population ages 21 to 40.
  
 //​**Rationale:​** // //​**Rationale:​** //
 Acne is a common and disabling medical condition, particularly amongst adolescents and young adults.[1] ​ According to the Global Burden of Disease Study 2016, acne is the most disabling skin condition worldwide, responsible for 0.28% of global burden from all diseases.[2] ​ In addition to physical disfigurement,​ the profound psychosocial effects of acne have been recognized for over half a century.[3] ​ Guidelines established by the American Academy of Dermatology recommend minimizing the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] ​ A recent systematic review demonstrated that over 50% of P. acnes strains are reported as resistant in all major regions of the world.[4] ​ In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis,​ as well as possible associations with inflammatory bowel disease and obesity.[5] ​ Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[5] ​ A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[5] ​ A similar retrospective cohort study of teenagers and young adults in the US found that 18% of antibiotic courses exceeded 6 months.[6] ​ Our study will investigate oral antibiotic use for acne over the last ten years across the globe in both pediatric/​young adult and adult populations. ​ OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance//​.//​ Acne is a common and disabling medical condition, particularly amongst adolescents and young adults.[1] ​ According to the Global Burden of Disease Study 2016, acne is the most disabling skin condition worldwide, responsible for 0.28% of global burden from all diseases.[2] ​ In addition to physical disfigurement,​ the profound psychosocial effects of acne have been recognized for over half a century.[3] ​ Guidelines established by the American Academy of Dermatology recommend minimizing the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] ​ A recent systematic review demonstrated that over 50% of P. acnes strains are reported as resistant in all major regions of the world.[4] ​ In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis,​ as well as possible associations with inflammatory bowel disease and obesity.[5] ​ Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[5] ​ A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[5] ​ A similar retrospective cohort study of teenagers and young adults in the US found that 18% of antibiotic courses exceeded 6 months.[6] ​ Our study will investigate oral antibiotic use for acne over the last ten years across the globe in both pediatric/​young adult and adult populations. ​ OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance//​.//​
  
-**Project Lead(s):​** ​ //Chante Karimkhani, ​Robert P. Dellavalle, Lisa M. Schilling//+**Project Lead(s):​** ​ //Robert P. Dellavalle, Lisa M. Schilling//
  
 **Coordinating Institution(s):​** //​University of Colorado School of Medicine// **Coordinating Institution(s):​** //​University of Colorado School of Medicine//
  
-**Additional Participants:​** // //+**Additional Participants:​** // //Chante Karimkhani: ck2525@caa.columbia.edu ​  
 +Chandler Rundle: chandler.rundle@gmail.com 
 +Megan Branda: MEGAN.BRANDA@cuanschutz.edu 
 +John Barbieri: john.barbieri@uphs.upenn.edu 
 +Chris Knoll: cknoll1@its.jnj.com 
 +David Margolis: margo@mail.med.upenn.edu  
 +Patrick Ryan: ryan@ohdsi.org  
 +Martijn Schuemie: m.schuemie@erasmusmc.nl  
 +Jonathan Silverberg: JonathanISilverberg@gmail.com  
 +Dylan Ray: DYLAN.RAY@cuanschutz.edu 
 +Sara Deakyne: Sara.DeakyneDavies@childrenscolorado.org
  
 **Full Draft Protocol:** //Please provide any comments or suggestions.//​ **Full Draft Protocol:** //Please provide any comments or suggestions.//​
research/concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris.txt · Last modified: 2020/01/06 13:28 by crundle