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--- projects:workgroups:transfusion [2019/12/02 12:56] – cgreich
+++ projects:workgroups:transfusion [2019/12/13 04:05] (current) – cgreich
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 ==== OHDSI Transfusion Working Group ====
+<WRAP box justify round>
 === MISSION ===
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 Extend OMOP CDM and Vocabulary and OHDSI analytic platform to support transfusion research
-Transfusions are special treatments which are currently in active research by the FDA BEST and the [[REDS-IV|https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evaluation-study-reds-program]] program.
+Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap.
+</WRAP>
+== Use Cases ==
+  * Effect of number of units on outcomes
+  * Effect of single donor vs pooled on outcomes
+  * Effect agency blood products are obtained from (such as ARC vs NYBC) on outcomes
+  * Incidence rates of severe outcomes: TRALI, TACO, Sepsis, HTRs, PTP, thrombosis and others
+  * Fatality rates of outcomes
+  * Incidence rates of outcomes by specific blood products transfused: red blood cells, plasma, platelets, full blood
+  * Incidence rates of outcomes by blood component processing: leukocyte reduction, irradiation, pathogen-reduction
+  * Incidence rates of outcomes by indication and associated procedures and other possible risk factors
+  * Incidence rates of outcomes by donor characteristics
+== Modelling Issues ==
+  * Detailed facts about transfused units, such as
+   * Manipulation: cultured enrichment, demineralization, genetical modification,
+   * Concentration, dosage, portioning and unit of issue,
+   * Preservation: irradiation and pathogen reduction, transport, storage, cryoprotection,
+   * monitoring: preparation, processing, mobilization, modification, quarantine,
+   * Additive, excipient and nutrient content
+  * Dose
+  * Units
+  * Route
+  * Start/End Time
+  * Multiple touch points of interest (prescribe/dispense/admin)
+  * Lab results specific to the unit for unit-specific data (product CD34+ vs patient CD34+)
 * [[projects:workgroups:transfusion:members|Participants]]
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 * [[documentation:transfusion:Data_Source|Data Repository]]