The group agreed to explore the onco domains in the following order:
- Diagnosis
- Treatment
- Outcomes survival
- Molecular biomarkers
- Pathology reports
- Imaging
- Performance status
Existing standards
· Tumor Registry, CDISC and SEER are the existing standards and efforts in harmonizing the data collection.
Exploratory data set
· Christian would try putting together a working data set
ICD-O-3 overview
Michael Gurley's ICD-O-3 Presentation and proposal for CDM cancer diagnosis modeling
- ICD-O-3 provides most granular representation of cancer diagnosis including anatomic side and morphological/behavior.
- Diagnosis can be represented in condition_occurence
ICD-O-3 Mapping
- Iker suggested that NCI Metatethaurus provides mapping of ICD-O-3 to SNOMED and some other vocabularies
- Memorial Sloan Kettering (MSK) Oncotree mapping
At MSK we maintain a cancer tumor terminology called oncotree (which is publicly available) http://oncotree.mskcc.org/oncotree/
We also have a public API that maps ICDO site and histology combinations to Oncotree concepts, which at the same time are mapped to NCI Thesaurus and UMLS, see http://oncotree.mskcc.org/oncotree-mappings/
An example for that API would be http://oncotree.mskcc.org/oncotree-mappings/crosswalk?vocabularyId=ICDO&conceptId=&histologyCode=8490/3&siteCode=C16.1