projects:workgroups:transfusion
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projects:workgroups:transfusion [2019/12/02 12:56] cgreich |
projects:workgroups:transfusion [2019/12/13 04:05] (current) cgreich |
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| ==== OHDSI Transfusion Working Group ==== | ==== OHDSI Transfusion Working Group ==== | ||
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| + | <WRAP box justify round> | ||
| === MISSION === | === MISSION === | ||
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| Extend OMOP CDM and Vocabulary and OHDSI analytic platform to support transfusion research | Extend OMOP CDM and Vocabulary and OHDSI analytic platform to support transfusion research | ||
| - | Transfusions are special treatments which are currently in active research by the FDA BEST and the [[REDS-IV|https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evaluation-study-reds-program]] program. | + | Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap. |
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| + | </WRAP> | ||
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| + | == Use Cases == | ||
| + | |||
| + | * Effect of number of units on outcomes | ||
| + | * Effect of single donor vs pooled on outcomes | ||
| + | * Effect agency blood products are obtained from (such as ARC vs NYBC) on outcomes | ||
| + | * Incidence rates of severe outcomes: TRALI, TACO, Sepsis, HTRs, PTP, thrombosis and others | ||
| + | * Fatality rates of outcomes | ||
| + | * Incidence rates of outcomes by specific blood products transfused: red blood cells, plasma, platelets, full blood | ||
| + | * Incidence rates of outcomes by blood component processing: leukocyte reduction, irradiation, pathogen-reduction | ||
| + | * Incidence rates of outcomes by indication and associated procedures and other possible risk factors | ||
| + | * Incidence rates of outcomes by donor characteristics | ||
| + | |||
| + | == Modelling Issues == | ||
| + | |||
| + | * Detailed facts about transfused units, such as | ||
| + | * Manipulation: cultured enrichment, demineralization, genetical modification, | ||
| + | * Concentration, dosage, portioning and unit of issue, | ||
| + | * Preservation: irradiation and pathogen reduction, transport, storage, cryoprotection, | ||
| + | * monitoring: preparation, processing, mobilization, modification, quarantine, | ||
| + | * Additive, excipient and nutrient content | ||
| + | * Dose | ||
| + | * Units | ||
| + | * Route | ||
| + | * Start/End Time | ||
| + | * Multiple touch points of interest (prescribe/dispense/admin) | ||
| + | * Lab results specific to the unit for unit-specific data (product CD34+ vs patient CD34+) | ||
| * [[projects:workgroups:transfusion:members|Participants]] | * [[projects:workgroups:transfusion:members|Participants]] | ||
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| * [[documentation:transfusion:Data_Source|Data Repository]] | * [[documentation:transfusion:Data_Source|Data Repository]] | ||
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projects/workgroups/transfusion.1575291369.txt.gz · Last modified: 2019/12/02 12:56 by cgreich
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