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Treatment Pathways in Chronic Disease

Objective: The objective of this study is to characterize the prevalence of different treatment pathways for three chronic diseases: Hypertension, Type II Diabetes, and Depression. We will systematically summarize the treatment pathways observed among patients who have at least 3 years of continuous observation and persistent treatment following initiation. We will stratify the results by year to evaluate temporal trends, and will further stratify by data source to determine if treatment pathways vary by population, geography, and data capture process.

Rationale: While numerous treatment guidelines exist for chronic conditions, there is a paucity of data on the real-world treatment pathways that patients experience in practice. Understanding these pathways is essential for establishing context around questions of drug utilization, effectiveness, and adherence.

Project Leads: Patrick Ryan, Jon Duke, George Hripcsak, Martijn Schuemie, Nigam Shah

Coordinating Institution(s): Janssen R&D, Columbia University, Regenstrief Institute, Stanford University

Additional Participants:

Full Protocol: Hypertension Treatment Pathways 12-4-2014

Initial Proposal Date: 12/3/2014

Launch Date: 12/5/2014

Study Closure Date: 12/31/2014

Results Submission: Email or SFTP


CDM: V4 or V5

Database Dialect: SQL Server, Postgres, Oracle

Software: SQL as above, R (optional)



Datasets Run

  • Truven
  • Optum
  • CPRD
  • Indiana Network for Patient Care
research/treatment_pathways_in_chronic_disease.txt · Last modified: 2014/12/06 21:04 by jduke