Date Submitted: October 1, 2018
Date Approved: October 23, 2018
Author(s): Jeff Smith, MD
Organization: Wincester Institute, Scotland, UK
Modality: (Rule-Based or Computational)
Current Implementation: http://www.ohdsi.org/web/atlas/#/cohortdefinition/100145}Atlas Phenotype
This definition is intended to capture patients with a first-observed diagnosis of chronic rheumatoid arthritis (RA), taking care to rule out patients with short-term joint pain or fibromyalgia.
This phenotype was developed by a group of 4 expert rheumatologists, who gathered and identified key condition codes that manifest in individuals with RA, along with drug combinations that almost exclusively identify RA patients.
|10/11/2018||1.1||Included extra RA descendents introduced in newly released OMOP CDM Version 6.||(Link)|
The phenotype has been validated at the following sites, with the following metrics:
TP = True Positive FP = False Positive TN = True Negative FN = False Negative PPV = Positive Predictive Value NPV = Negative Predictive Value
Site A represents a large Midwestern academic medical center. Site B is a hospital in a mostly rural area in the Southeastern US. Site C represents proprietary EU patient data licensed by a large research organization
At each site, chart review was independently performed by 2 rheumatologists on a randomly selected subset (5%) of patients satisfying the phenotype definition.
At Site B, the small sample size was likely due to a lack of an on-site rheumatology clinic.
i.e. Flowcharts or other diagrams that may be helpful to an end user
This phenotype will be re-reviewed in October 2022.