The LEGEND (Large-scale Evidence Generation and Evaluation across a Network of Databases) Initiative applies high-level analytics to perform observational research on hundreds of millions of patient records within OHDSI’s international database network.
LEGEND principles have been applied to studying the effects of treatments for depression, hypertension, and COVID-19, and are being applied to Type 2 diabetes. The clinical impact of LEGEND has already been observed, with important evidence that promotes better health decisions published in Lancet, JAMA Internal Medicine, and Hypertension.
During the Oct. 19 OHDSI Community Call, members of the LEGEND team provided a comprehensive presentation around this initiative, its work around hypertension, and plans around Type 2 diabetes.