Save Our Sisyphus Challenge

The OHDSI mission is to improve health by empowering a community to collaboratively generate the evidence that promotes better health decisions and better care. The 2023 Save Our Sisyphus (SOS) Challenge attempted to fulfill that mission, but not through one study at a time.

Our community simultaneously collaborated on four studies, each of which were designed, implemented, executed and will ultimately be disseminated by members of the OHDSI global community.

As you can see on the right, there were two weekly tutorials  taught by different members of the 

the community. These focused on two of the four studies (see below), but they also serve as educational tools for people who plan to lead or participate in a network study in the future.


• While tutorials for the SOS Challenge have concluded, work on the studies are ongoing. Cindy Cai, who is leading the Anti-VEGF study, announced that data partners are being accepted through July 14, 2023; her interpretation on the first study results is available here. Jack Janetzki, Seng Chan You and the fluoroquinolone also provided a results interpretation session last week, and they announced that weekly meetings would continue at their regular time through the end of July.

SOS Challenge Studies

Intravitreal Anti-VEGF and Kidney Failure ​

Lead: Cindy Cai

Is fluoroquinolone use really associated with the development of aortic aneurysms

Leads: Jack Janetzki, Jung Ho Kim, Seonji Kim,
Jung Ah Lee, Nicole Pratt, Seng Chan You,

Amongst people with psoriasis, does exposure to Risankizumab increase the risk of cerebrovascular events while on treatment relative to other biologic therapies?

Lead: Zenas Yiu

Characterization: incidence of progressive multifocal leukoencephalopathy (PML) during Multiple Sclerosis (MS) biologic exposure

Lead: Thamir Alshammary

Tutorial Recordings

Week 9: Interpreting the Results

Session 1: Cindy Cai (slides)
Session 2: Jack Janetzki, Seng Chan You

Week 8: Evidence Synthesis

Session 1: Yong Chen (slides), Martijn Schuemie (slides)
Session 2: Marc Suchard

Week 7: Study Diagnostics

Session 1: Fan Bu, George Hripcsak (slides)
Session 2: Mitchell Conover, Nicole Pratt (slides)

Week 6: Network Execution

Session 1: Jenna Reps, Jack Brewster (slides)
Session 2: Anthony Sena, Chungsoo Kim

Week 5: Analysis Design

Session 1: Patrick Ryan (slides)
Session 2: Patrick Ryan (slides)

Week 4: Phenotype Evaluation

Session 1: James Gilbert, Azza Shoaibi (slides)
Session 2: James Gilbert, Evan Minty

Special Extra Tutorial: PheValuator

PheValuator: Joel Swerdel

Week 3: Phenotype Development

Session 1a: Anna Ostropolets – Outcome Design
Session 1b: Asieh Golozar – Exposure Design
Session 2a: Christian Reich – Exposure Design
Session 2b: Gowtham Rao – Outcome Design

Week 2: Data Diagnostics

Session 1: Clair Blacketer, Mui Van Zandt, Sarah Seager (slides)
Session 2: Mui Van Zandt/Jing Li

Week 1: Initiating A Network Study

Session 1: Marc Suchard
Session 2: Seng Chan You